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It should be administered on an empty stomach at least 1 hour before food or 2 hours after food. sildenafil: [noun] a drug that is used in the form of its citrate C22H30N6O4S·C6H8O7 to treat erectile dysfunction in males, that by suppressing a phosphodiesterase enzyme also suppresses the enzyme's inhibitory effect on the hormone cyclic GMP, and that enables the cyclic GMP produced during sexual arousal to initiate the muscular and. Consider therapy modification. These include grapefruit and grapefruit juice, fatty meals, nitrate-rich foods, excessive caffeine, and excessive alcohol. Viagra works by increasing blood flow to the penis, which allows for a man to get and keep an erection. Viagra can last up to 5 hours or longer depending on your dosage, your. Sildenafil, the original PDEI, was introduced in 1998. Even if this drug is covered by Medicare or your insurance, we recommend you compare. 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